Related Experiment Video
Updated: Feb 15, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
Comparing Topical Treatments for Basal Cell Carcinoma
Fiona M Shaw1, Martin A Weinstock2
1Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Center for Dermatoepidemiology, Veterans Affairs Medical Center, Providence, Rhode Island, USA.
Imiquimod is more effective than 5-fluorouracil or photodynamic therapy in preventing superficial basal cell carcinoma recurrence after five years. Treatment decisions should consider toxicity, cost, and patient preferences.
Area of Science:
- Dermatology
- Oncology
Background:
- Superficial basal cell carcinoma (a type of keratinocyte carcinoma) has rising incidence and significant morbidity.
- Effective treatment strategies are crucial for managing this common skin cancer.
Purpose of the Study:
- To compare the efficacy of imiquimod, 5-fluorouracil, and methyl aminolevulinate photodynamic therapy in preventing superficial basal cell carcinoma recurrence.
- To provide long-term follow-up data on treatment outcomes.
Main Methods:
- A randomized trial was conducted with a 5-year follow-up period.
- Patients with superficial basal cell carcinoma were treated with imiquimod, 5-fluorouracil, or methyl aminolevulinate photodynamic therapy.
Main Results:
- Imiquimod demonstrated higher effectiveness in preventing superficial basal cell carcinoma recurrence compared to 5-fluorouracil and methyl aminolevulinate photodynamic therapy.
- The study provides 5-year follow-up data supporting imiquimod's long-term efficacy.
Conclusions:
- Imiquimod is a more effective topical treatment for superficial basal cell carcinoma recurrence prevention than the other evaluated therapies.
- Clinical decisions require balancing treatment efficacy with considerations of toxicity, cost, and individual patient preferences.
More Related Videos
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
04:09Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
Published on: October 10, 2018
Related Concept Videos
Laminins are the Adhesive Proteins of Basal Lamina
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
Basal Lamina are the Specialized Form of ECM
Proteins...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can...
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
Comparative Excretory Systems