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Updated: Feb 15, 2026

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia
Published on: May 6, 2016
Effect of repetitive transcranial magnetic stimulation on action myoclonus: A pilot study in patients with EPM1
Davide Rossi Sebastiano1, Adriana Magaudda2, Angelo Quartarone3
1Neurophysiopathology and Epilepsy Centre Unit, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.
Objective:
The objective of this study was to explore the short-term effects of repetitive transcranial magnetic stimulation (rTMS) on action myoclonus.
Methods:
Nine patients with Unverricht-Lundborg (EPM1) progressive myoclonus epilepsy type underwent two series of 500 stimuli at 0.3Hz through round coil twice a day for five consecutive days. Clinical and neurophysiological examinations were performed two hours before starting the first rTMS session and two hours after the end of the last rTMS session.
Results:
Eight patients completed the protocol; one discontinued because of a transient increase in spontaneous jerks. The unified myoclonus rating scale indicated a 25% reduction in posttreatment myoclonus with action score associated with an increase in the cortical motor threshold and lengthening of the cortical silent period (CSP). The decrease in the myoclonus with action scores correlated with the prolongation of CSP.
Conclusions:
Repetitive transcranial magnetic stimulation can be safely used in patients with EPM1, improves action myoclonus, and partially restores deficient cortical inhibition.
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