Related Experiment Video

Updated: Feb 15, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
06:54

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

11.8K

Clinical and molecular features of treatment-related neuroendocrine prostate cancer

Shusuke Akamatsu1, Takahiro Inoue1, Osamu Ogawa1

  • 1Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

International Journal of Urology : Official Journal of the Japanese Urological Association
|February 4, 2018
PubMed

Insights

Treatment-related neuroendocrine prostate cancer (tNETPC) arises from prostate adenocarcinoma adapting to treatment. Key genomic alterations like MYCN gain and TP53/RB1 loss drive this aggressive cancer, necessitating new therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Treatment-related neuroendocrine prostate cancer (tNETPC) is an aggressive variant emerging during castration-resistant prostate cancer (CRPC) treatment.
  • It arises from adenocarcinoma transdifferentiation in response to androgen receptor pathway inhibition (ARPI).
  • Rising incidence correlates with increased use of potent ARPIs, posing a clinical challenge due to poor prognosis.

Purpose of the Study:

  • To elucidate the molecular mechanisms driving tNETPC development.
  • To identify key genomic alterations and molecular pathways involved in tNETPC transdifferentiation.
  • To inform the development of novel therapeutic strategies and biomarkers for tNETPC.

Main Methods:

  • Genomic and molecular characterization of tNETPC.
  • Analysis of key genetic alterations including oncogene gain (MYCN, AURKA) and tumor suppressor loss (TP53, RB1).
  • Investigation of gene expression changes in AR-repressed genes (BRN2, PEG10) and lineage plasticity regulators (SOX2, EZH2).

Main Results:

  • Key genomic alterations in tNETPC include MYCN and AURKA oncogene gain, and TP53 and RB1 tumor suppressor gene loss.
  • Androgen receptor-repressed genes (BRN2, PEG10) are crucial for tNETPC.
  • Genetic changes activate pathways (SOX2, EZH2) promoting lineage plasticity and neuroendocrine differentiation.

Conclusions:

  • tNETPC develops through clonal divergence and transdifferentiation of CRPC under potent ARPI.
  • Understanding these molecular drivers is essential for developing targeted therapies.
  • Further research into tNETPC biology is critical for improving treatment outcomes.
Keywords:
neuroendocrineprostate cancersmall cell carcinoma

More Related Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K
Pre-clinical Orthotopic Murine Model of Human Prostate Cancer07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

15.1K

Related Concept Videos

Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
17
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
710
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
563
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
364
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
342