Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
03:56

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

1.3K

FRAX calculated without BMD does not correctly identify Caucasian men with densitometric evidence of osteoporosis

R C Hamdy1, E Seier2, K Whalen3

  • 1Osteoporosis Center, East Tennessee State University, Johnson City, TN, 37614, USA. Hamdy@etsu.edu.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|February 5, 2018
PubMed

Insights

The FRAX tool, without bone mineral density (BMD) data, is not sensitive or specific enough to identify osteoporosis in Caucasian men aged 50-70. Further evaluation is needed for accurate osteoporosis diagnosis in this demographic.

Area of Science:

  • Endocrinology
  • Geriatrics
  • Bone Metabolism

Background:

  • Osteoporosis diagnosis relies on bone mineral density (BMD), fragility fractures, or elevated fracture risk.
  • The FRAX algorithm estimates 10-year osteoporotic fracture probability, calculable with or without BMD data.

Purpose of the Study:

  • To evaluate the accuracy of the FRAX tool, when used without BMD data, in identifying osteoporosis in men.
  • To determine if FRAX scores without BMD can correctly identify patients with BMD-defined osteoporosis in a male cohort.

Main Methods:

  • Retrospective analysis of data from 726 Caucasian males aged 50-70 years.
  • FRAX scores were calculated and compared against BMD-defined osteoporosis thresholds.

Main Results:

  • Using female reference populations, 11.8% of men had osteoporosis; using male reference populations, 25.3% had osteoporosis.
  • When using National Osteoporosis Foundation thresholds, only 27% of patients with osteoporosis met treatment criteria, while 4% with normal BMD did.
  • Adjusting thresholds improved sensitivity but reduced specificity.

Conclusions:

  • FRAX assessment without BMD data lacks sufficient sensitivity and specificity for identifying osteoporosis in Caucasian men aged 50-70.
  • Current FRAX application without BMD may lead to misdiagnosis or delayed treatment initiation in this population.

Keywords:
Bone mineral densityFRAXManagementMenOsteoporosis

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.6K
Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

1.1K

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.4K
Distance Corrections01:15

Distance Corrections

To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
303
Power Factor Correction01:20

Power Factor Correction

The power transmission to a factory involves the transfer of apparent power, a combination of active and reactive power. The power factor measures how effectively electrical power is converted into useful work output. The ratio of the real power (KW) that does the work to the apparent power (KVA) supplied to the circuit.
562
Calculating the Equilibrium Constant02:46

Calculating the Equilibrium Constant

The equilibrium constant for a reaction is calculated from the equilibrium concentrations (or pressures) of its reactants and products. If these concentrations are known, the calculation simply involves their substitution into the Kc expression.
For example, gaseous nitrogen dioxide forms dinitrogen tetroxide according to this equation:
38.3K
Calculating Standard Free Energy Changes02:49

Calculating Standard Free Energy Changes

The free energy change for a reaction that occurs under the standard conditions of 1 bar pressure and at 298 K is called the standard free energy change. Since free energy is a state function, its value depends only on the conditions of the initial and final states of the system. A convenient and common approach to the calculation of free energy changes for physical and chemical reactions is by use of widely available compilations of standard state thermodynamic data. One method involves the...
25.8K
Calculating pH Changes in a Buffer Solution02:45

Calculating pH Changes in a Buffer Solution

A buffer can prevent a sudden drop or increase in the pH of a solution after the addition of a strong acid or base up to its buffering capacity; however, such addition of a strong acid or base does result in the slight pH change of the solution. The small pH change can be calculated by determining the resulting change in the concentration of buffer components, i.e., a weak acid and its conjugate base or vice versa. The concentrations obtained using these stoichiometric calculations can be used...
59.0K