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Related Experiment Video

Updated: Feb 15, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Red man syndrome caused by vancomycin powder.

Yasunori Nagahama1, Marta J VanBeek2, Jeremy D W Greenlee1

  • 1Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|February 6, 2018
PubMed
Summary

Red man syndrome (RMS), a vancomycin hypersensitivity reaction, was observed after local wound application, not just IV use. This case highlights a new risk associated with vancomycin powder in surgical prophylaxis.

Area of Science:

  • Neurosurgery
  • Pharmacology
  • Clinical Medicine

Background:

  • Red man syndrome (RMS) is a known hypersensitivity reaction to intravenous vancomycin.
Keywords:
Anaphylactoid reactionComplicationInfection prophylaxisPerioperative antibioticRed man syndromeVancomycin powder

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  • Local vancomycin powder application is increasingly used for surgical infection prophylaxis, particularly in neurosurgery.
  • RMS has not been previously documented following local intra-wound vancomycin powder administration.