Related Experiment Video
Updated: Feb 15, 2026
09:49
Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
Published on: November 8, 2014
13.1K
Techniques Used to Localize Occult Breast Lesions: An Update
Matthew Green1, Raghavan Vidya1
1Department of Breast Surgery, New Cross Hospital, Wolverhampton, United Kingdom.
Clinical Breast Cancer
|February 6, 2018
Summary
The increasing availability of breast cancer screening leads to more impalpable lesions. This review examines current and emerging techniques for localizing these occult breast tumors, comparing their advantages and disadvantages.
Area of Science:
- Radiology
- Oncology
- Medical Devices
Background:
- Growing availability of breast cancer screening programs globally increases the detection of impalpable breast pathologies.
- The market for breast lesion localization techniques is expanding, projected to exceed $1 billion by 2024.
- Accurate localization is crucial for effective treatment of impalpable breast lesions.
Purpose of the Study:
- To review existing and novel techniques for the localization of impalpable breast lesions.
- To discuss the advantages and disadvantages of each reviewed localization method.
- To provide an overview of the current landscape and future trends in breast lesion localization.
Main Methods:
- Literature review of current breast lesion localization techniques.
- Comparative analysis of different localization methods based on efficacy, accessibility, and patient comfort.
- Discussion of emerging technologies in the field.
Main Results:
- Several "tried and tested" techniques exist for localizing occult breast lesions.
- A growing number of alternative localization methods are entering the market.
- Each technique presents a unique set of pros and cons influencing clinical adoption.
Conclusions:
- The increasing prevalence of impalpable breast pathology necessitates a thorough understanding of available localization techniques.
- The choice of localization method depends on various factors including lesion characteristics and clinical setting.
- Continued innovation in localization technologies is expected to meet growing clinical demand.
Related Concept Videos
01:22Local Attraction
399
Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
399
01:13Local Anesthetics: Pharmacokinetics
1.3K
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
1.3K
01:22Absolute and Local Extreme Values
91
The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
91
01:12Local Anesthetics: Adverse Effects
822
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
822
01:46Nuclear Localization Signals and Import
7.8K
Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of 2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
7.8K
01:23Local Anesthetics: Mechanism of Action
3.4K
Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
3.4K