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Related Experiment Video

Updated: Feb 15, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

A practical background correction method for an immediately repeated first-pass radionuclide angiography.

Lien-Hsin Hu¹, Liang-Chih Wu¹, Chien-Ying Lee¹

¹Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA

|February 6, 2018

Summary

A new method corrects background interference in first-pass radionuclide angiography (FPRNA) after suboptimal bolus injections. This technique improves the accuracy of ejection fraction measurements, avoiding repeat studies and ensuring reliable cardiac function assessment.

Keywords:

Background correction Background interference Background subtraction Ejection fraction First-pass radionuclide angiography Image processing

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Published on: May 18, 2011

Area of Science:

Nuclear Medicine
Cardiovascular Imaging
Radiology

Background:

First-pass radionuclide angiography (FPRNA) requires satisfactory bolus injections for accurate results.
Suboptimal injections lead to background interference, often necessitating study rescheduling.
A novel protocol was developed to correct pre-existing background activity.

Purpose of the Study:

To develop and validate a method for correcting background activity in FPRNA.
To assess the impact of background correction on ejection fraction (EF) measurements.
To improve the reliability of FPRNA by avoiding repeat procedures.

Main Methods:

Seventy-four patients undergoing same-day bone scan and FPRNA were analyzed.
Ejection fraction (EF) was calculated from initial and repeated injections, with and without background correction.
A subset of patients had clearance constants determined for enhanced background correction.

Main Results:

The corrected ejection fraction (EF2') showed significantly smaller mean differences compared to the uncorrected EF2 for both left and right ventricles (LV and RV).
Mean differences for LV were 1.6 ± 2.1% (corrected) vs. 3.1 ± 2.0% (uncorrected).
Mean differences for RV were 1.8 ± 1.8% (corrected) vs. 2.2 ± 1.9% (uncorrected).

Conclusions:

Immediate re-administration of bolus injection in FPRNA can underestimate LVEF and RVEF.
The developed correction method provides superior results compared to uncorrected data.
This protocol enhances the accuracy of FPRNA, particularly when initial injections are suboptimal.