Correlation of hyperglycemia with mortality after acute ischemic stroke

Area of Science:

• Neurology
• Endocrinology
• Critical Care Medicine

Background:

• Hyperglycemia is a known predictor of stroke outcomes.
• This study investigates the link between blood glucose levels in the first 24 hours post-stroke and patient outcomes.
• Focus is on mortality and hemorrhagic transformations in non-diabetic patients.

Purpose of the Study:

• To determine the correlation between blood glucose levels within 24 hours of stroke onset and patient outcomes.
• To assess the impact of persistent hyperglycemia on mortality and hemorrhagic transformation.
• To evaluate the predictive value of early glucose measurements for stroke prognosis.

Main Methods:

• Ninety-one non-diabetic patients with acute ischemic stroke were studied.
• Blood glucose was measured at baseline (within 6 hours) and hourly for 24 hours.
• Patients were grouped based on hyperglycemia patterns (normoglycemia, baseline, 24-hour, persistent).

Main Results:

• Persistent hyperglycemia correlated with a significantly increased risk of 30-day mortality (OR = 24.0) and hemorrhagic transformation within 7 days (OR = 13.3).
• Neither baseline nor delayed hyperglycemia alone showed a correlation with adverse outcomes.
• These findings highlight the prognostic significance of sustained high blood glucose levels.

Conclusions:

• Persistent hyperglycemia is a strong predictor of mortality following acute ischemic stroke.
• Continuous glucose monitoring in the early phase of stroke is vital for risk stratification.
• The study underscores the importance of managing hyperglycemia to improve stroke outcomes.