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Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development.

Mayank Chaturvedi1, Manish Kumar2, Kamla Pathak3

  • 1Department of Pharmaceutics, Rajiv Academy for Pharmacy, Chattikkara, Mathura, India.

Advanced Pharmaceutical Bulletin
|February 6, 2018
PubMed
Summary

Surface solid dispersion (SSD) of meloxicam (MLX) with crospovidone (CPV) showed enhanced solubility and dissolution. This approach led to superior orodispersible tablets with rapid drug release compared to traditional solid dispersions.

Keywords:
DissolutionOrodispersible tabletSolid dispersionSurface solid dispersion

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Meloxicam (MLX) solubility and dissolution rates are critical for effective oral administration.
  • Traditional solid dispersions (SD) can improve drug bioavailability but may have limitations.
  • Surface solid dispersion (SSD) offers a potential alternative for enhanced drug delivery.

Purpose of the Study:

  • To comparatively evaluate surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX).
  • To enhance meloxicam solubility and dissolution.
  • To develop patient-friendly orodispersible tablets from optimized formulations.

Main Methods:

  • Meloxicam (MLX) was formulated into SSD using crospovidone (CPV) and SD using PEG4000.
  • Preparation methods included co-grinding and solvent evaporation at drug: carrier ratios of 1:1, 1:4, and 1:8.
  • Optimized formulations were developed into orodispersible tablets and evaluated for disintegration, wetting time, water absorption, and drug release.

Main Results:

  • The SSD formulation (SSDS3, MLX:CPV 1:8, solvent evaporation) exhibited superior performance (t50% = 28 min, 80.9% DE50min) compared to the corresponding SD (SDS3, t50% = 35 min, 76.4% DE50min).
  • The orodispersible tablet F3, prepared with SSD3, demonstrated significantly better characteristics (11s disintegration, 6s wetting time, 78% water absorption, 97% cumulative drug release) than the SD3 tablet.
  • SSD significantly improved meloxicam's dissolution profile.

Conclusions:

  • Surface solid dispersion (SSD) of meloxicam is a promising approach for enhancing solubility and dissolution.
  • SSD-based orodispersible tablets offer advantages in terms of rapid disintegration and complete drug release.
  • This technology holds potential for developing fast-acting meloxicam formulations.