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Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR
Published on: February 12, 2018
A case report of spontaneous staphylococcal meningitis in a cynomolgus monkey
Zhi Lin1, Lu Zhang2, Di Zhang1
1National Institute for Food and Drug Control, National Center for Safety Evaluation of Drugs, Beijing Key Lab for Pre-clinical Safety Evaluation of Drugs, Beijing, China.
Abstract:
This report describes a suppurative meningitis in a young cynomolgus. The animal had neutrophil aggregation in the subarachnoid space and hemorrhage in bilateral adrenal glands. Staphylococcus was identified by FISH in brain. To our knowledge, this is the first case of staphylococcal meningitis with Waterhouse-Friderichsen syndrome in a cynomolgus monkey.
Insights
This study reports the first known case of Staphylococcus-induced meningitis complicated by Waterhouse-Friderichsen syndrome in a young cynomolgus monkey, highlighting a rare but severe condition in non-human primates.
Area of Science:
- Veterinary Pathology
- Primate Medicine
- Infectious Diseases
Background:
- Suppurative meningitis is a serious condition affecting the central nervous system.
- Waterhouse-Friderichsen syndrome is a severe form of meningococcemia characterized by adrenal hemorrhage.
- Cynomolgus monkeys are important models in biomedical research.
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