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Noteworthy Literature published in 2017 for Cardiothoracic Anesthesiologists
Dirk J Varelmann1, Jochen Daniel Muehlschlegel1
11 Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Insights
Large 2017 studies in cardiac surgery and heart failure offer insights into new treatments like levosimendan and methylprednisolone, alongside methods to reduce transfusions and device choices.
Area of Science:
- Cardiothoracic Anesthesiology
- Cardiovascular Medicine
- Critical Care Medicine
Background:
- 2017 saw major clinical studies impacting cardiac surgery and heart failure (HF) management.
- Key areas included inotropic agents, corticosteroids, blood transfusion strategies, and mechanical circulatory support.
- These studies highlight advancements in perioperative cardiovascular care.
Purpose of the Study:
- To review significant 2017 clinical studies relevant to cardiothoracic anesthesiologists.
- To summarize findings on levosimendan, methylprednisolone, rotational thromboelastometry, aortic valve replacement, and ventricular assist devices.
- To underscore the evolving landscape of perioperative cardiovascular medicine.
Main Methods:
- Review of large-scale clinical studies and randomized controlled trials published in 2017.
- Focus on interventions in cardiac surgery and heart failure patients.
- Analysis of outcomes related to specific treatments and devices.
Main Results:
- Studies investigated levosimendan as an inotropic agent in HF patients undergoing cardiac surgery.
- Research reported on the effects of high-dose methylprednisolone on recovery and delirium.
- Rotational thromboelastometry use was examined for reducing transfusion needs.
- Outcomes of surgical vs. transcatheter aortic valve replacement and different ventricular assist devices were compared.
Conclusions:
- The reviewed studies demonstrate significant progress and emerging trends in perioperative cardiovascular medicine.
- Findings provide critical data for optimizing patient management in cardiac surgery and heart failure.
- The dynamic nature of the field necessitates continuous evaluation of new evidence and technologies.
Abstract:
The year 2017 was a year dominated by large-scale clinical studies reporting the outcome of various interventions in cardiac surgery and heart failure (HF) patients, relevant to all cardiothoracic anesthesiologists. Among them were studies investigating the addition of levosimendan, an alternative inotropic agent, to standard management of patients with HF undergoing cardiac surgery. Also, corticosteroids have been used for various purposes in cardiac patients. Here, a new study reports the effect of high-dose methylprednisolone on recovery and delirium. Furthermore, with increasing evidence that transfusions increase morbidity and mortality, a publication reports the use of rotational thromboelastometry to reduce transfusion requirements. In addition, several randomized controlled multicenter studies report the outcomes of patients undergoing cardiac procedures: surgical versus transcatheter aortic valve replacement in intermediate-risk patients and the use of centrifugal-flow versus axial-flow left-ventricular devices in patients with HF. These studies demonstrate the dynamic and ever-evolving state of perioperative cardiovascular medicine and show us the direction of future developments.
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