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Updated: Feb 14, 2026
05:51
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
18.6K
Multidirectional Estimation of Arterial Stiffness Using Vascular Guided Wave Imaging with Geometry Correction.
Yuexin Guo1, Yahua Wang1, Enoch Jing-Han Chang1
1Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong.
Ultrasound in Medicine & Biology
|February 7, 2018
Summary
Vascular guided wave imaging (VGWI) can now assess arterial stiffness in multiple directions. Correcting for geometric factors improves accuracy, enabling better characterization of arterial health and anisotropy.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Cardiovascular Research
Background:
- Non-invasive quantification of arterial wall stiffness is crucial for assessing cardiovascular health.
- Existing methods often lack multidirectional assessment capabilities, limiting characterization of arterial anisotropy and plaque effects.
- Vascular guided wave imaging (VGWI) previously showed potential for quantifying stiffness in longitudinal and circumferential directions.
Purpose of the Study:
- To investigate the multidirectional estimation of arterial Young's modulus using VGWI.
- To evaluate the impact of geometric factors (shape factor) on guided wave propagation and modulus estimation.
- To validate the ability of VGWI to portray anisotropic mechanical properties in arterial models and biological samples.
Main Methods:
- Developed and applied a finite-element model, in vitro artery-mimicking phantoms, and an excised porcine aorta.
- Introduced longitudinal pre-stretch and lumen pressure to emulate arterial mechanical anisotropy.
- Utilized a zero-order antisymmetric Lamb wave model for guided wave propagation approximation.
- Calculated shape factor (inner radius to thickness ratio) across full radial rotations (0°-360°).
Main Results:
- View-dependent geometry, specifically low shape factors (<1.5), caused Young's modulus overestimation in specific angular intervals.
- Excluding these low shape factor regions corrected the modulus overestimation, as validated by mechanical tensile testing.
- VGWI successfully portrayed the anisotropy of hollow cylindrical structures and the porcine aorta using derived fractional anisotropy values.
Conclusions:
- Excluding geometric artifacts is essential for accurate multidirectional Young's modulus estimation via VGWI.
- VGWI demonstrates capability in characterizing the anisotropic mechanical properties of arteries.
- This study advances the potential for 3-D assessment of arterial mechanical properties.
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