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Novel single-nucleotide variations associated with vancomycin resistance in vancomycin-intermediate Staphylococcus

Lee-Chung Lin1, Shih-Cheng Chang1,2, Mao-Cheng Ge1

  • 1Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Infection and Drug Resistance
|February 7, 2018
PubMed
Summary

Prolonged vancomycin use can lead to vancomycin-intermediate Staphylococcus aureus (VISA). This study identified novel genetic variations in VISA and heterogeneous VISA strains, suggesting specific amino acid changes in FmtC, HtrA, and Upps are linked to vancomycin resistance.

Keywords:
MRSAVISAVSSAhVISA

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