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Related Concept Videos

Biofilms01:29

Biofilms

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Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
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Bacterial Signaling01:30

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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Growth of Mycobacterium tuberculosis Biofilms
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Growth of Mycobacterium tuberculosis Biofilms

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Mycobacterium Biofilms.

Jaime Esteban1, Marta García-Coca1

  • 1Department of Clinical Microbiology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid, Spain.

Frontiers in Microbiology
|February 7, 2018
PubMed
Summary
This summary is machine-generated.

Mycobacterial biofilms, a key virulence factor, enhance resistance to antibiotics and disinfectants. Understanding and eradicating these biofilms are crucial for treating infections caused by Mycobacterium species.

Keywords:
MycobacteriumMycobacterium avium complexMycobacterium tuberculosisantimicrobial resistancebiofilmsin vitro studyrapidly growing mycobacteriareview

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biomaterials Science

Background:

  • The genus Mycobacterium comprises human pathogens like Mycobacterium tuberculosis and environmental non-tuberculous mycobacteria (NTM).
  • Biofilm formation is a common pathogenic mechanism in mycobacteria, contributing to chronic infections, particularly when associated with biomaterials.
  • Mycobacterial biofilms exhibit increased resistance to environmental stressors and disinfectants compared to their planktonic counterparts.

Purpose of the Study:

  • To explore the role of biofilms in mycobacterial pathogenesis and antimicrobial resistance.
  • To highlight the significance of biofilm eradication in managing mycobacterial infections.
  • To discuss emerging strategies for combating biofilm formation.

Main Methods:

  • Confocal laser scanning microscopy was used to study mycobacterial biofilm ultrastructure and phenotypic characteristics.
  • Literature review on biofilm formation, pathogenicity, and treatment strategies in mycobacteria.

Main Results:

  • Biofilm formation is a critical factor in the pathogenicity of both M. tuberculosis and NTM, influencing disease progression and antimicrobial resistance.
  • Mycobacterial biofilms are implicated in respiratory diseases, biomaterial-associated infections, and the pathology of tuberculosis.
  • Biofilms protect mycobacteria from antibiotics, necessitating physical eradication and novel therapeutic approaches.

Conclusions:

  • Understanding mycobacterial biofilm formation is essential for effective patient management, especially in non-tuberculous mycobacteria (NTM) diseases.
  • The discovery of M. tuberculosis biofilms opens new avenues for research and therapeutic development.
  • Targeting biofilm formation presents a promising strategy to overcome antimicrobial resistance in mycobacterial infections.