Pulmonary Mucormycosis Over 130 Years: A Case Report and Literature Review
Hasan S Yamin1, Amro Y Alastal1, Izzedin Bakri2
1Pulmonary, Critical Care and Sleep Medicine Division, Internal Medicine Department, Makassed Hospital, Mount of Olives, Jerusalem, Palestine.
Turkish Thoracic Journal
|February 7, 2018
Summary
Pulmonary mucormycosis, a severe fungal infection caused by Mucor, poses a high mortality risk in immunocompromised individuals. This review examines 130 years of evolving treatment strategies and their impact on patient survival.
Area of Science:
- Mycology
- Infectious Diseases
- Medical History
Background:
- Mucor is a ubiquitous fungus, typically noninvasive in healthy individuals.
- In immunocompromised patients, Mucor can cause life-threatening angioinvasive pulmonary mucormycosis.
- Pulmonary mucormycosis is characterized by high mortality rates.
Purpose of the Study:
- To review the historical management of pulmonary mucormycosis over 130 years.
- To analyze the impact of changing treatment strategies on mortality.
- To provide insights into the evolution of antifungal therapies.
Main Methods:
- Historical literature review.
- Analysis of treatment modalities and outcomes.
- Tracking mortality trends over time.
Main Results:
- Early management strategies had limited efficacy.
- Advances in antifungal drugs and surgical techniques have improved outcomes.
- Despite progress, mortality remains significant.
Conclusions:
- Management of pulmonary mucormycosis has evolved significantly.
- Improved diagnostics and targeted therapies are crucial.
- Continued research is needed to further reduce mortality.
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