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Estrogens and Their Receptors in Prostate Cancer: Therapeutic Implications

Erika Di Zazzo1, Giovanni Galasso1, Pia Giovannelli1

  • 1Department of Biochemistry, Biophysics and General Pathology, University of Campania Luigi Vanvitelli, Naples, Italy.

Frontiers in Oncology
|February 7, 2018
PubMed

Insights

Targeting the estradiol/estradiol receptor (ER) axis offers a promising strategy to combat prostate cancer (PC) growth and metastasis. Selective ER subtype targeting may inhibit prostatic cancer cell proliferation and spread.

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Prostate cancer (PC) management faces challenges in limiting tumor growth and preventing metastasis.
  • Current therapies often lead to resistance and progression to castration-resistant forms.
  • Alterations in nuclear receptors, including the estradiol/estradiol receptor (ER) axis, are frequently observed in PC.

Purpose of the Study:

  • To review the role of the estradiol/estradiol receptor (ER) axis in prostate cancer (PC) growth and progression.
  • To explore the potential of selectively targeting ER subtypes (α or β) for PC therapy.

Main Methods:

  • Literature review of preclinical and clinical findings.
  • Analysis of the impact of the estradiol/estradiol receptor (ER) axis on PC.
  • Evaluation of selective ER subtype targeting strategies.

Main Results:

  • The estradiol/estradiol receptor (ER) axis plays a significant role in controlling PC growth and progression.
  • Selective targeting of ER subtypes (α or β) shows potential for PC treatment.

Conclusions:

  • The estradiol/estradiol receptor (ER) axis is a critical factor in prostate cancer (PC) pathogenesis.
  • Selective modulation of ER subtypes presents a viable therapeutic avenue to inhibit PC growth and metastasis.
Keywords:
castrate resistant prostate cancerestradiolestradiol receptorsnew drugsprostate cancer

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