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Updated: Feb 14, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
miRNA displacement as a promising approach for cancer therapy
David Gilot1,2,3, Marie-Dominique Galibert1,2,3,4
1CNRS UMR 6290, IGDR, 2 avenue Pr Léon Bernard 35043 Rennes, France.
Abstract:
microRNA (miRNA) are critical post-transcriptional regulators and key players in diseases development. We demonstrated that non-canonical microRNA Responsive Elements (here MRE-16) could sequester miR-16, dampening miR-16 tumor suppressor function. We developed small oligonucleotides, masking specifically these unusual miR-16 binding sites, that restored miR-16 function. This constitutes a promising targeted approach.
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