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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Better Together: A Win-Win Pediatric Academic Partnership.

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    Academic practice partnerships between healthcare facilities and universities enhance nursing education and patient care. These collaborations improve evidence-based practice, research, and access to services for underserved families.

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    Area of Science:

    • Nursing Education and Practice
    • Healthcare Management and Partnerships

    Background:

    • Healthcare systems face challenges in efficiency and effectiveness.
    • Academic practice partnerships are increasingly recognized for their value.
    • Existing literature highlights the benefits of collaboration between nursing academia and practice.

    Purpose of the Study:

    • To describe the initiatives, processes, and outcomes of an academic practice partnership.
    • To illustrate the application of the American Association of Colleges of Nursing (AACN) and American Organization of Nurse Executives (AONE) Academic Practice Partnership Guiding Principles.
    • To provide adaptable examples for other healthcare facilities and nursing programs.

    Main Methods:

    • Collaboration between a children's hospital and a state university.
    • Utilizing the AACN and AONE Academic Practice Partnership Guiding Principles.
    • Implementing initiatives focused on key areas of partnership.

    Main Results:

    • Improved evidence-based practice and research.
    • Creation of innovative educational opportunities for students.
    • Enhanced academic progression for nurses.
    • Increased access to healthcare services for underserved families.
    • Implementation of patient- and family-centered care initiatives.

    Conclusions:

    • The described academic practice partnership has yielded fruitful outcomes.
    • The partnership successfully addressed key areas including education, research, and patient care.
    • The guiding principles and initiatives offer a transferable model for other institutions.