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Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics
João Sargento-Freitas1, Sezin Aday2, César Nunes3
1Centro Hospitalar e Universitário de Coimbra, Portugal; Faculdade de Medicina da Universidade de Coimbra, Portugal; Centro Neurociências e Biologia Celular, Coimbra, Portugal.
Journal of the Neurological Sciences
|February 7, 2018
Summary
Functional properties of Endothelial Progenitor Cells (EPCs) correlate with acute stroke hemodynamics, aiding angiogenesis. EPCs
Area of Science:
- Neuroscience
- Regenerative Medicine
- Cardiovascular Research
Background:
- Endothelial Progenitor Cells (EPCs) promote angiogenesis post-ischemia.
- EPC integration with stroke reperfusion therapies and hemodynamic evolution remains unclear.
Purpose of the Study:
- To investigate the association between EPCs and acute, subacute, and chronic hemodynamic features in stroke patients.
Main Methods:
- Prospective study of 45 ischemic stroke patients (18-80 years).
- Hemodynamic evaluation (CBF, recanalization, collateral flow) via ultrasound at baseline, 7 days, and 3 months.
- EPC isolation, counting, and in vitro functional tests; MRI for hemorrhagic transformation.
Main Results:
- EPC angiogenic and migratory capacities linked to acute collateral flow and 7-day CBF.
- No significant association found between EPCs and recanalization or hemorrhagic transformation.
- EPC number did not correlate with any hemodynamic variable.
Conclusions:
- Functional EPC properties are associated with acute and subacute stroke hemodynamics.
- EPCs do not appear to influence hemorrhagic transformation.
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