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Muscle Tissue Remodeling Following Intramuscular Fat Grafting: Structural And Transcriptomic Insights.

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Muscle Tissue Remodeling Following Intramuscular Fat Grafting: Structural And Transcriptomic Insights.

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A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle

A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle

Published on: May 26, 2022

Muscle Tissue Remodeling Following Intramuscular Fat Grafting: Structural and Transcriptomic Insights.

Mário Mendanha¹, Raquel Soares², Carla Luís²

¹Vitruvian Life Research Center, Porto, Portugal.

Aesthetic Surgery Journal

|June 22, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Autologous fat grafting via the PRIME-GRAFT technique improves muscle tissue by reducing fibrosis and enhancing gene expression related to regeneration and metabolism. This body contouring method offers histological and transcriptomic benefits beyond aesthetics.

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A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle

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Published on: May 26, 2022

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

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Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography

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Area of Science:

Regenerative Medicine
Plastic Surgery
Molecular Biology

Background:

Autologous fat grafting is a body contouring technique for aesthetic refinement.
Emerging evidence suggests potential biological adaptations within grafted muscle tissue.
The study investigates the biological effects of intramuscular fat grafting.

Purpose of the Study:

To evaluate the biological implications of intramuscular fat grafting.
To assess histological and transcriptomic changes in fat-grafted muscle.
To understand the regenerative potential induced by autologous fat transfer.

Main Methods:

Retrospective within-subject controlled study.
Paired muscle biopsies (pectoralis major vs. vastus lateralis) from 7 male patients one year post-PRIME-GRAFT.
Histological and transcriptome analyses performed on biopsies.

Main Results:

Reduced fibrosis and elevated glycogen concentrations in fat-grafted muscle.
Transcriptome analysis revealed 70 differentially expressed genes.
Upregulation of genes associated with muscle structure, metabolism, and regeneration.

Conclusions:

PRIME-GRAFT technique shows histological and transcriptional evidence of improved muscle resilience and regeneration.
Autologous intramuscular fat transfer offers benefits beyond aesthetics, enhancing muscle integrity.
Findings suggest enhanced regenerative potential and homeostasis in treated muscle tissue.