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Updated: Feb 14, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Argentinean recommendations on the identification of treatment failure in relapsing remitting multiple sclerosis
Edgardo Cristiano1, Ricardo Alonso2, Amelia Alvez Pinheiro3
1Centro de esclerosis múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
Abstract:
One of the biggest challenges in multiple sclerosis (MS) is the definition of treatment response/failure in order to optimize treatment decisions in affected patients. The objective of this consensus was to review how disease activity should be assessed and to propose recommendations on the identification of treatment failure in RRMS patients in Argentina.
Methods:
A panel of experts in neurology from Argentina, dedicated to the diagnosis and care of MS patients, gathered both virtually and in person during 2016 and 2017 to carry out a consensus recommendation on the identification of treatment failure in RRMS patients. To achieve consensus, the methodology of "formal consensus-RAND/UCLA method" was used.
Results:
Recommendations were established based on published evidence and the expert opinion. Recommendations focused on disease management, disease activity markers and treatment failure identification were determined. Main consensus were: ≥2 relapses during the first year of treatment and/or ≥3 new or enlarged T2 or T1 GAD+ lesions and/or sustained increase of ≥2 points in EDSS or ≥100% in T25FW defines treatment failure in RRMS patients.
Conclusions:
The recommendations of this consensus guidelines attempts to optimize the health care and management of patients with MS in Argentina.
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