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Zika Virus Infection in Children

David Taylor Hendrixson1, Jason G Newland1

  • 1Department of Pediatrics, Division of Infectious Diseases, Washington University in St. Louis, St. Louis Children's Hospital, Campus Box 8116, 1 Children's Place, St Louis, MO 63110, USA.

Infectious Disease Clinics of North America
|February 7, 2018
PubMed

Insights

Zika virus, a mosquito-borne illness, can cause symptomatic and asymptomatic infections. Congenital Zika infections are linked to severe neurological issues in infants, requiring proactive screening and supportive care.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Zika virus is a Flavivirus transmitted by mosquitoes.
  • First identified in Africa, it caused sporadic febrile illness.
  • A major outbreak began in Brazil in 2015, with widespread symptomatic infections.

Purpose of the Study:

  • To summarize the characteristics of Zika virus infections.
  • To highlight the link between Zika virus and congenital abnormalities.
  • To outline current diagnostic and treatment approaches.

Main Methods:

  • Review of existing literature on Zika virus.
  • Analysis of diagnostic methods including real-time PCR and antibody detection.
  • Discussion of clinical manifestations and management strategies.

Main Results:

  • Zika virus causes both symptomatic and asymptomatic human infections.
  • Congenital Zika virus infections are associated with significant neurological abnormalities.
  • Diagnosis involves molecular or serological testing for the virus.

Conclusions:

  • Zika virus poses a significant public health threat, particularly concerning congenital infections.
  • Supportive treatment is standard, but early screening and intervention are crucial for affected infants.
  • Continued surveillance and research are necessary to manage Zika virus outbreaks.
Keywords:
Arthropod-borne diseaseCongenital infectionFlavivirusMicrocephalyVertical transmissionZika virus

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