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Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice
Published on: October 17, 2018
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Zika Virus Infection in Children
David Taylor Hendrixson1, Jason G Newland1
1Department of Pediatrics, Division of Infectious Diseases, Washington University in St. Louis, St. Louis Children's Hospital, Campus Box 8116, 1 Children's Place, St Louis, MO 63110, USA.
Infectious Disease Clinics of North America
|February 7, 2018
Summary
Zika virus, a mosquito-borne illness, can cause symptomatic and asymptomatic infections. Congenital Zika infections are linked to severe neurological issues in infants, requiring proactive screening and supportive care.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Zika virus is a Flavivirus transmitted by mosquitoes.
- First identified in Africa, it caused sporadic febrile illness.
- A major outbreak began in Brazil in 2015, with widespread symptomatic infections.
Purpose of the Study:
- To summarize the characteristics of Zika virus infections.
- To highlight the link between Zika virus and congenital abnormalities.
- To outline current diagnostic and treatment approaches.
Main Methods:
- Review of existing literature on Zika virus.
- Analysis of diagnostic methods including real-time PCR and antibody detection.
- Discussion of clinical manifestations and management strategies.
Main Results:
- Zika virus causes both symptomatic and asymptomatic human infections.
- Congenital Zika virus infections are associated with significant neurological abnormalities.
- Diagnosis involves molecular or serological testing for the virus.
Conclusions:
- Zika virus poses a significant public health threat, particularly concerning congenital infections.
- Supportive treatment is standard, but early screening and intervention are crucial for affected infants.
- Continued surveillance and research are necessary to manage Zika virus outbreaks.
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