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Expression, Purification, and Antimicrobial Activity of S100A12
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Chitosan-based nanosystems and their exploited antimicrobial activity.

Diego Romano Perinelli1, Laura Fagioli2, Raffaella Campana2

  • 1School of Pharmacy, University of Camerino, Via Gentile III da Varano, Camerino, MC, Italy.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|February 7, 2018
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Summary

Chitosan, a natural polymer, shows antimicrobial properties. Combining it with other substances in nanosystems enhances its effectiveness against bacteria and fungi for various applications.

Keywords:
Food packagingNanocompositesNanoparticlesPolycationPolysaccharideWound healing

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Area of Science:

  • Biomaterials Science
  • Microbiology
  • Nanotechnology

Background:

  • Chitosan is a biodegradable and biocompatible polysaccharide with diverse industrial applications.
  • Its inherent antibacterial and antifungal activities, coupled with a favorable safety profile, make it attractive for research.
  • Antimicrobial efficacy is influenced by chitosan's properties and microbial cell wall structure.

Purpose of the Study:

  • To review strategies for enhancing chitosan's antimicrobial activity using nanosystems.
  • To explore applications of chitosan-based nanosystems.
  • To highlight recent advancements in this field.

Main Methods:

  • Literature review of studies on chitosan-based nanosystems.
  • Analysis of factors affecting chitosan's antimicrobial activity.
  • Examination of synergistic approaches combining chitosan with other active agents.

Main Results:

  • Nanosystems effectively enhance the antimicrobial potential of chitosan.
  • Incorporation with drugs, metals, and natural compounds boosts efficacy.
  • Chitosan-based nanosystems show promise across pharmaceutical, biomedical, and industrial sectors.

Conclusions:

  • Chitosan-based nanosystems represent a promising strategy to overcome limitations of native chitosan.
  • Further research into these advanced materials can unlock broader applications.
  • Synergistic combinations are key to maximizing antimicrobial outcomes.