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Updated: Feb 14, 2026

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
Published on: December 16, 2013
Nepafenac loaded silica nanoparticles dispersed in-situ gel systems: Development and characterization
Muthuselvam Paulsamy1, Chandrasekar Ponnusamy2, Mohananarayanan Palanisami2
1Department of BioTechnology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamil Nadu, India.
Abstract:
This research was aimed to develop and evaluate nepafenac loaded silica nanoparticles dispersed in-situ gel system for the improved treatment of ocular diseases. The blank silica nanoparticles prepared by stober's process showed the particle size of 151 nm to 285 nm with the zeta potential of -19.6 to -31.9 mV. The nepafenac loaded silica nanoparticles were spherical in shape with smooth outer surface. The nepafenac loaded silica nanoparticles dispersed in poloxamer - chitosan in-situ gelling system showed gelling temperature of 32 °C with sustained release of nepafenac and higher permeation (58.79 μg) across the goat cornea than poloxamer - poloxamer (21.18 μg) in-situ gelling system. Hence the developed in-situ gelling system containing nepafenac loaded silica nanoparticle could be a promising tool for the topical delivery of drugs to the eye.
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