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Updated: Aug 10, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

[Sensitivity of fungi in the genus Candida to antimicrobial preparations]

G K Paliĭ, S A Ivanova

    Antibiotiki I Meditsinskaia Biotekhnologiia = Antibiotics and Medical Biotechnology
    |March 1, 1986
    PubMed

    Insights

    Decamethoxin demonstrated superior antifungal activity against Candida strains from chronic intestinal diseases. Resistance to decamethoxin developed slowly, with no cross-resistance observed with levorin.

    Area of Science:

    • Medical Mycology
    • Antimicrobial Resistance

    Background:

    • Candida species are opportunistic fungal pathogens.
    • Chronic intestinal diseases can predispose individuals to Candida infections.
    • Effective antifungal agents are crucial for managing these infections.

    Purpose of the Study:

    • To evaluate the antifungal sensitivity of Candida strains isolated from patients with chronic intestinal diseases.
    • To assess the development of resistance to decamethoxin and cross-resistance to levorin.

    Main Methods:

    • Testing the sensitivity of 50 Candida strains to amphotericin B, levorin, enteroseptol, intestopan, and decamethoxin.
    • Estimating the rate of resistant variant formation against decamethoxin.
    • Assessing cross-resistance development between decamethoxin and levorin.

    Main Results:

    • Decamethoxin exhibited the highest antifungal activity among the tested drugs.
    • The fungicidal concentration of enteroseptol ranged from 3.9-7.8 µg/ml for 78% of strains.
    • Candida albicans developed resistance to decamethoxin slowly, without reaching high levels.
    • No cross-resistance was detected between decamethoxin and levorin.

    Conclusions:

    • Decamethoxin is a highly effective antifungal agent against Candida strains from chronic intestinal diseases.
    • The slow development of resistance and lack of cross-resistance suggest decamethoxin's potential for sustained therapeutic use.
    • Enteroseptol and intestopan also showed significant fungicidal activity, warranting further investigation.

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