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Updated: Feb 14, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
Heterogeneous impacts: adverse childhood experiences and cancer screening
Héctor E Alcalá1, Emma M Mitchell2, Jessica Keim-Malpass2
1Department of Family, Population and Preventive Medicine; Program in Public Health, Stony Brook University, 101 Nicolls Road, Stony Brook, NY, 11794, USA. hectorapm@ucla.edu.
Background:
Adverse childhood experiences (ACEs) have been associated with higher odds of cancer in adulthood. One potential explanation for this association is the impact of ACEs on cancer screening. To address this shortcoming, this study examined how ACEs were associated with current compliance and ever use of prostate, breast, cervical, and colorectal cancer screening.
Methods:
Data from the 2014 Kansas Behavioral Risk Factor Surveillance System were used (n = 11,794). Logistic regressions were used to calculate odds of cancer screening behaviors from each of nine different ACE items and a count of ACEs.
Results:
Individual ACE items were associated with lower odds of compliance with PSA screening, clinical breast exam, and pap test guidelines. Certain ACEs were associated with increased odds of compliance with colorectal cancer screening guidelines among women and lower odds of compliance among men. ACEs were associated with ever screening for PSA and ever use of colonoscopy or sigmoidoscopy among men and women. Physical abuse was most consistently associated with cancer screening, across outcomes.
Conclusions:
Most significant associations showed that specific ACEs were associated with lower odds of cancer screening. Therefore, efforts should be made to promote screening among those with histories of ACEs.
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