Related Experiment Video
Updated: Feb 14, 2026
05:53
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
17.1K
Inflammation Strikes Again: Frailty and HIV
Stephanie M Fukui1, Damani A Piggott2,3, Kristine M Erlandson4,5
1School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Current HIV/AIDS Reports
|February 8, 2018
Summary
As people with HIV age, frailty becomes a concern. This review explores how inflammation contributes to frailty in HIV, suggesting inflammation-targeted therapies could improve health outcomes.
Area of Science:
- Gerontology
- Immunology
- Infectious Diseases
Background:
- The aging population of adults with human immunodeficiency virus (HIV) is increasing due to effective antiretroviral therapy.
- This demographic shift leads to a greater prevalence of age-related syndromes, including frailty.
- Frailty, characterized by increased vulnerability to stressors, predicts adverse outcomes in both HIV-infected and uninfected individuals.
Purpose of the Study:
- To review the current evidence linking inflammation and frailty in the context of HIV infection.
- To explore the potential of novel, inflammation-targeted interventions for managing frailty in aging HIV-infected adults.
Main Methods:
- Literature review of studies investigating the relationship between inflammation and frailty in HIV.
- Analysis of evidence supporting the role of inflammation in frailty pathogenesis.
- Evaluation of potential anti-inflammatory therapeutic strategies.
Main Results:
- Dysregulated inflammation is consistently associated with frailty in elderly populations, including those with HIV.
- Inflammation is a key factor in HIV pathophysiology and has been shown to be associated with frailty in HIV-infected individuals.
- Preliminary evidence suggests anti-inflammatory therapies may help mitigate frailty in aging adults with HIV.
Conclusions:
- Understanding the pathogenesis of frailty in HIV is crucial for developing effective interventions.
- Inflammation plays a significant role in frailty among aging HIV-infected adults.
- Further research into inflammation-targeted therapies is warranted to improve health outcomes in this population.
Related Concept Videos
01:38Inflammation
62.5K
Overview
62.5K
02:26Photoelectric Effect
39.8K
When light of a particular wavelength strikes a metal surface, electrons are emitted. This is called the photoelectric effect. The minimum frequency of light that can cause such emission of electrons is called the threshold frequency, which is specific to the metal. Light with a frequency lower than the threshold frequency, even if it is of high intensity, cannot initiate the emission of electrons. However, when the frequency is higher than the threshold value, the number of electrons ejected...
39.8K
00:36Viral Mutations
40.0K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
40.0K
02:16Light Acquisition
9.6K
In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
9.6K
02:18X-ray Crystallography
26.3K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
26.3K
04:10What is Energy?
59.7K
The universe is composed of matter in different forms, and all forms of matter contain energy. The different forms of energy on Earth originate from the Sun — the ultimate energy source. Plants capture light energy from the Sun, and, via the process of photosynthesis, convert it into chemical energy. This stored energy from plants can be harnessed in many ways. For example, eating plant products as food provides energy for our body to function, and burning wood or coal (fossilized...
59.7K