Related Experiment Video
Updated: Feb 14, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin
Hye Jung Park1, Kyung Soo Suk2, Jung Won Park3
1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. craft7820@yuhs.ac.
Abstract:
Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized. Skin test and specific immunoglobulin E test showed positive results for bovine thrombin and beef, respectively. During the second stage of operation (After 10 days from first stage of operation), bovine-derived thrombin powder was excluded and the operation was successful without any unexpected events. Therefore, bovine thrombin should be used with caution because it might cause anaphylaxis.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Measurement: Derived Units
Higher Derivatives
Derivatives
Derivatives: Problem Solving
First Derivative Test: Problem Solving

