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Updated: Feb 14, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
Published on: November 12, 2012
Hollow Pt-Functionalized SnO2 Hemipill Network Formation Using a Bacterial Skeleton for the Noninvasive Diagnosis of
Hi Gyu Moon, Youngmo Jung, Dukwoo Jun
1Institute for Pure and Applied Mathematics , University of California , Los Angeles , California 90095 , United States.
Abstract:
Hollow-structured nanomaterials are presented as an outstanding sensing platform because of their unique combination of high porosity in both the micro- and nanoscale, their biocompatibility, and flexible template applicability. Herein, we introduce a bacterial skeleton method allowing for cost-effective fabrication with nanoscale precision. As a proof-of-concept, we fabricated a hollow SnO2 hemipill network (HSHN) and a hollow Pt-functionalized SnO2 hemipill network (HPN). A superior detecting capability of HPN toward acetone, a diabetes biomarker, was demonstrated at low concentration (200 ppb) under high humidity (RH 80%). The detection limit reaches 3.6 ppb, a level satisfying the minimum requirement for diabetes breath diagnosis. High selectivity of the HPN sensor against C6H6, C7H8, CO, and NO vapors is demonstrated using principal component analysis (PCA), suggesting new applications of HPN for human-activity monitoring and a personal healthcare tool for diagnosing diabetes. The skeleton method can be further employed to mimic nanostructures of biomaterials with unique functionality for broad applications.
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