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Updated: Feb 14, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
[Obsessive compulsive disorder and deep brain stimulation, a future so close]
João Flores Alves Dos Santos1, Paul Krack2,3, Shahan Momjian4
1Service de psychiatrie de liaison et d'intervention de crise, Département de santé mentale et de psychiatrie, HUG, 1211 Genève 14.
Abstract:
The obsessive compulsive disorder (OCD) is a psychiatric disorder with a high prevalence (2‑3 %), frequently causing a disabling condition. Drug and psychotherapeutic treatment is generally effective. However about 1/3 of the patients are treatment-resistant, suffering from chronic psychological distress with important sociofunctional repercussions. The identification of dysfunctional neural networks in this disease opens the door to the use of neuromodulation techniques, as deep brain stimulation (DBS). We discuss the clinical results of subthalamic nucleus DBS and the involvement of this nucleus in the pathophysiology of OCD. We emphasize the importance to confirm these results with a larger number of patients and to determine the benefits regarding the quality of life of implanted patients.
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