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Updated: Feb 14, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Advances in the Conceptualization and Study of Schizophrenia in Later Life
Carl I Cohen1, Ksenia Freeman1, Dina Ghoneim1
1Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Abstract:
A crisis looms as research and clinical programs have not kept pace with dramatic increases in the number of older adults with schizophrenia. This article provides an overview of the advances in the conceptualization and study of schizophrenia in later life. Theoretic and clinical models in psychiatry and gerontology are integrated. Specifically, recovery is examined in the context of aging, how clinical dimensionality affects diagnoses in older adults, how various features of schizophrenia are implicated in models of accelerated and paradoxic aging, and how outcome in later life is a more dynamic and heterogeneous than assumed previously.
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