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Related Concept Videos

Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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What are Proteins?01:55

What are Proteins?

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Overview
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Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Updated: Feb 14, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

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Computational Resources for Predicting Protein-Protein Interactions.

Himani Tanwar1, C George Priya Doss1

  • 1School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.

Advances in Protein Chemistry and Structural Biology
|February 8, 2018
PubMed
Summary
This summary is machine-generated.

Computational methods accelerate the study of protein interactions, crucial for understanding cellular functions. This review highlights advanced tools and databases for predicting protein-protein interactions, aiding biological research.

Keywords:
Protein–protein interactionProtein–protein interaction databasesProtein–protein interaction networksProtein–protein interaction tools

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Area of Science:

  • Molecular Biology
  • Bioinformatics

Background:

  • Proteins are fundamental cellular components driving organismal functions.
  • Protein interactions form networks essential for biological processes.
  • Experimental methods for studying protein interactions are low-throughput and labor-intensive.

Purpose of the Study:

  • To review computational advancements and tools for predicting protein-protein interactions.
  • To describe major databases for protein interaction data.
  • To discuss the advantages and limitations of computational prediction tools.

Main Methods:

  • Review of computational techniques for protein interaction prediction.
  • Analysis of high-throughput experimental data.
  • Description of protein interaction databases.

Main Results:

  • Computational methods offer high-throughput analysis of protein interactions.
  • Various tools and databases are available for predicting and storing protein interactions.
  • Specific advantages and limitations of computational tools are identified.

Conclusions:

  • Computational approaches significantly enhance the study of protein interaction networks.
  • Understanding the strengths and weaknesses of these tools is vital for researchers.
  • This review provides a guide to computational resources for biologists.