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Updated: Feb 14, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
14:22

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

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Transforming Biomarker Development with Exceptional Responders

Philip Jonsson1, Barry S Taylor2

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Trends in Cancer
|February 8, 2018
PubMed

Insights

Understanding rare outlier responses in advanced cancer is key. Phenotype-to-genotype studies reveal the molecular basis, aiming to extend these profound cancer therapy benefits to more patients.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Curative treatment for advanced-stage cancer remains a significant challenge.
  • Rare instances of exceptional responses to anticancer therapies offer potential insights.
  • Understanding the molecular and genetic drivers of these outlier responses is limited.

Purpose of the Study:

  • To investigate the molecular underpinnings of outlier responses to anticancer therapies.
  • To leverage phenotype-to-genotype correlations for deeper understanding.
  • To inform strategies for extending exceptional treatment sensitivity to a wider patient group.

Main Methods:

  • Utilizing phenotype-to-genotype studies.
  • Analyzing molecular and genetic data from patients with outlier responses.
  • Correlating clinical observations with genomic profiles.

Main Results:

  • Phenotype-to-genotype studies are successfully elucidating the molecular basis of outlier anticancer therapy responses.
  • These studies provide a framework for understanding the genetic factors contributing to profound treatment sensitivity.
  • Identified molecular underpinnings offer potential targets for therapeutic development.

Conclusions:

  • Phenotype-to-genotype analysis is a powerful approach to unraveling the biology of exceptional cancer treatment responses.
  • This research informs the development of novel therapeutic strategies.
  • The goal is to translate insights from outlier responders to benefit broader patient populations with advanced cancer.
Keywords:
exceptional responsegenomicsmolecular oncologyprecision medicinesequencing

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