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Self-sterilizing ormosils surfaces based on photo-synzthesized silver nanoparticles
Lidiane Patrícia Gonçalves1, Alejandro Miñán2, Guillermo Benítez2
1Grupo de Química de Materiais Híbridos e Inorgânicos, Prédio de Química Ambiental, Instituto de Química de São Carlos, Universidade de São Paulo, 13563-120, São Carlos, SP, Brazil.
Colloids and Surfaces. B, Biointerfaces
|February 8, 2018
Summary
A novel antibacterial coating, POrs-CS-Ag, effectively eradicates bacteria like Staphylococcus aureus and Pseudomonas aeruginosa. This self-sterilizing material shows sustained antimicrobial activity through multiple uses, offering a promising solution for medical devices.
Area of Science:
- Materials Science
- Biotechnology
- Nanotechnology
Background:
- Medical device-related infections pose significant patient risks.
- Antimicrobial materials are crucial for preventing bacterial colonization and biofilm formation.
- Current antimicrobial materials often require combination therapies for complete eradication.
Purpose of the Study:
- To develop a robust antibacterial coating using Phosphotungstate Ormosil doped with core-shell (SiO2@TiO2) and silver nanoparticles (Ag NPs).
- To evaluate the efficacy of the developed coating against common bacterial strains.
- To assess the durability and reusability of the antimicrobial activity.
Main Methods:
- Sol-gel process, chemical tempering, and photoassisted synthesis of Ag NPs were employed.
- Characterization techniques included X-ray Fluorescence Spectroscopy (XRF), FE-SEM, AFM, and XPS.
- Antibacterial activity was tested against Staphylococcus aureus and Pseudomonas aeruginosa.
Main Results:
- Silver-free coatings exhibited limited antibacterial activity.
- Silver-loaded coatings (POrs-CS-Ag) demonstrated complete eradication of tested bacterial strains.
- Antimicrobial efficacy remained high through three reuse cycles.
Conclusions:
- The developed POrs-CS-Ag coating is a promising self-sterilizing material.
- This technology can be applied to various materials, including fabrics, indwelling metals, and polymers.
- The coating offers a durable and effective strategy against medical device-related infections.
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