Related Experiment Video
Updated: Feb 6, 2026
08:31
Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
Published on: September 12, 2025
836
Pathogenesis of Peripheral T Cell Lymphoma.
Marco Pizzi1,2, Elizabeth Margolskee1, Giorgio Inghirami1,3,4
1Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA;
Annual Review of Pathology
|February 8, 2018
Summary
Peripheral T cell lymphomas (PTCLs) are aggressive cancers. Recent research reveals key transformation mechanisms, paving the way for novel combination therapies targeting cancer cells and their microenvironment.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Peripheral T cell lymphomas (PTCLs) are a diverse group of aggressive cancers with poorly understood origins.
- Decades of research have sought to identify the normal cell counterparts and pathogenic mechanisms driving PTCL development.
Purpose of the Study:
- To review the current understanding of PTCL pathogenesis.
- To highlight novel therapeutic strategies for managing these aggressive tumors.
Main Methods:
- Review of recent scientific literature on PTCL.
- Analysis of molecular mechanisms of T cell transformation.
- Evaluation of emerging therapeutic approaches.
Main Results:
- PTCL pathogenesis involves deregulation of T cell signaling pathways.
- Tumor microenvironment remodeling and virus-mediated T cell alterations are key factors.
- Understanding these mechanisms is crucial for developing targeted therapies.
Conclusions:
- Novel therapies combining conventional agents, new-generation compounds, and immunomodulators show promise.
- Targeting both neoplastic cells and the tumor microenvironment is essential for effective PTCL treatment.
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