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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Correlation between the corpus callosum index and brain atrophy, lesion load, and cognitive dysfunction in multiple
Lucas Immich Gonçalves1, Giordani Rodrigues Dos Passos2, Lucas Piccoli Conzatti2
1School of Medicine; Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Multiple Sclerosis and Related Disorders
|February 8, 2018
Summary
The corpus callosum index (CCI) is a reliable MRI marker for brain atrophy and lesion load in multiple sclerosis (MS). It correlates well with corpus callosum volume and cognitive function.
Area of Science:
- Neuroimaging
- Neurology
- Medical Diagnostics
Background:
- The corpus callosum index (CCI) is a potential marker for brain atrophy in multiple sclerosis (MS), derivable from conventional MRI.
- Further validation of CCI's correlation with volumetric measurements is needed.
Purpose of the Study:
- To evaluate the correlation of the CCI with corpus callosum volume (CCV), brain and lesion volumes, and disability levels in MS patients.
- To validate the CCI as a reliable MRI-based marker in MS.
Main Methods:
- Cross-sectional, exploratory study of relapsing-remitting MS patients.
- Clinical assessments included physical and cognitive disability scales.
- MRI analysis involved conventional volumetric measurements, manual CCI, and automated CCV.
Main Results:
- A strong correlation was observed between the CCI and CCV.
- The CCI strongly correlated with white matter and lesion volumes, and moderately with whole brain volume and cognitive tests (Paced Auditory Serial Addition Test, MS Functional Composite).
- No correlations were found between CCI and gray matter volume or specific disability scales (EDSS, 9-Hole Peg Test, Timed 25-Foot Walk).
Conclusions:
- The CCI is a valid, easily obtainable MRI marker for brain atrophy, lesion burden, and cognitive impairment in MS.
- Findings support the use of CCI in clinical practice for MS assessment.
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