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Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
Published on: August 8, 2019
Inter-operator variability in compartmental kinetic analysis of 18F-fluoromisonidazole dynamic PET
Sadek A Nehmeh1, Jazmin Schwartz2, Milan Grkovski2
1Weill Cornell Medical College, New York, NY, United States.
Purpose:
To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET.
Methods:
Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed.
Results:
Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs. Study-II: Up to 103% variability in tumor segmentation, and weaker ICC in KRCs (ICC-VB = 0.53; ICC-K1 = 0.91; ICC-K1/k2 = 0.25; ICC-k3 = 0.32; ICC-Ki = 0.54) existed. All KRCs were repeatable among the different operators.
Conclusions:
Inter-operator variability in CA of dyn-FMISO was shown to be within statistical errors.
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