Date seed oil loaded niosomes: development, optimization and anti-inflammatory effect evaluation on rats

Area of Science:

• Pharmacology and Drug Delivery
• Nanotechnology
• Natural Product Chemistry

Background:

• Date seed oil (DSO) possesses anti-inflammatory properties.
• Osteoarthritis (OA) requires effective anti-inflammatory treatments.
• Nanoparticle-based drug delivery systems can enhance therapeutic efficacy.

Purpose of the Study:

• To formulate optimized date seed oil (DSO) loaded niosomes.
• To enhance the anti-inflammatory efficacy of DSO.
• To control the release characteristics of DSO from nanoparticles for OA management.

Main Methods:

• Utilized Box-Behnken Design to optimize formulation factors.
• Assessed entrapment efficiency, initial release (2h), and cumulative release (12h) of DSO.
• Characterized optimized niosomes for particle size, zeta potential, morphology, and in vivo anti-inflammatory activity using a rat paw edema model.

Main Results:

• Optimized niosomes achieved 65.89% entrapment efficiency, 18.39% initial release, and 58.27% cumulative release.
• Confirmed nano-sized vesicular structure with good stability.
• Demonstrated significant prompt and sustained anti-inflammatory activity in vivo.

Conclusions:

• DSO loaded niosomes significantly enhance inflammation alleviation.
• This formulation presents a promising approach for osteoarthritis remediation and prevention.
• Niosomal encapsulation improves the therapeutic potential of date seed oil.