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Related Experiment Video

Updated: Feb 22, 2026

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Do LRG1-SERPINA1 Interactions Modulate Fibrotic and Inflammatory Signatures in Rheumatoid Arthritis? A Proteomic and

Talib Hussain1,2, Monika Verma1, Sagarika Biswas1,2

  • 1Integrative and Functional Biology Department, Council of Scientific & Industrial Research (CSIR)-Institute of Genomics and Integrative Biology, Mall Road, Delhi University Campus, Delhi 110007, India.

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) involves inflammation and fibrosis. This study found Leucine Rich Alpha2glycoprotein1 (LRG1) may promote RA by inhibiting the anti-inflammatory protein SERPINA1.

Keywords:
LRG1Rheumatoid arthritisfibrosisinflammationmolecular dynamics

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Area of Science:

  • Proteomics
  • Immunology
  • Computational Biology

Background:

  • Rheumatoid arthritis (RA) is a systemic autoimmune disease causing joint inflammation and fibrosis.
  • Proteomic analysis aids in understanding RA pathogenesis.
  • Fibrotic processes contribute significantly to RA progression.

Purpose of the Study:

  • To compare differentially upregulated proteins in RA with those linked to fibrosis.
  • To investigate the role of Leucine Rich Alpha2glycoprotein1 (LRG1) in RA-associated fibrosis.
  • To elucidate the interaction between LRG1 and Serine Protease Inhibitor Clade A, Member 1 (SERPINA1) in RA.

Main Methods:

  • Analysis of plasma proteomics data using Sequential Window Acquisition of all Theoretical Fragment Ion Mass Spectra (SWATH-MS/MS).
  • In silico methods to identify common proteins between RA and fibrosis.
  • Molecular docking and simulation studies to analyze protein interactions.

Main Results:

  • Common proteins associated with both RA and fibrosis were identified.
  • LRG1 and SERPINA1 exhibited high co-expression and a strong interaction.
  • LRG1 was identified as a pro-inflammatory and pro-fibrotic protein, while SERPINA1 acts as an anti-inflammatory inhibitor.

Conclusions:

  • LRG1 may promote RA inflammation and fibrosis by inhibiting SERPINA1's function.
  • The interaction between LRG1 and SERPINA1 is crucial in RA pathogenesis.
  • Targeting the LRG1-SERPINA1 interaction could offer therapeutic strategies for RA.