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Published on: October 17, 2018
Considerations for the Long Term Treatment of Pediatric Sarcoma Survivors
Kurt R Weiss1, Melissa N Zimel2
1Department of Orthopaedic Surgery, Division of Musculoskeletal Oncology, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA.
Insights
Pediatric sarcoma survivors face long-term health issues. Multidisciplinary clinics can improve their transition to adulthood and overall well-being.
Area of Science:
- Pediatric Oncology
- Cancer Survivorship
- Connective Tissue Malignancies
Background:
- Sarcomas are rare adult cancers but more common in children.
- Advances in cytotoxic chemotherapy have improved pediatric sarcoma prognoses.
- A growing population of pediatric sarcoma survivors are transitioning to adulthood.
Purpose of the Study:
- To highlight the long-term physical, medical, and psychological challenges faced by pediatric sarcoma survivors.
- To discuss the unique difficulties these survivors present to adult primary care physicians.
- To propose multidisciplinary sarcoma survivorship clinics as a solution.
Main Methods:
- Review of existing literature on pediatric sarcoma treatment outcomes.
- Analysis of long-term health sequelae in pediatric sarcoma survivors.
- Discussion of challenges in adult primary care for this population.
Main Results:
- Pediatric sarcoma survivors are at risk for physical disabilities, cardiac issues, second malignancies, and anxiety.
- These complex health needs pose challenges for general adult healthcare providers.
- Multidisciplinary clinics offer a structured approach to managing survivor care.
Conclusions:
- Pediatric sarcoma survivors require specialized, ongoing care into adulthood.
- Multidisciplinary sarcoma survivorship clinics are essential for addressing the unique needs of these patients.
- Improved management can enhance the long-term physical and emotional health of survivors.
Abstract:
Sarcomas are primary malignancies of the connective tissues. They are exceedingly rare in adults, but much more common in children. The historically recent advent of cytotoxic chemotherapy for pediatric sarcomas has revolutionized the treatment of these diseases and dramatically improved their prognoses. There is thus a population of pediatric sarcoma survivors that are "coming of age" as adults. However, this progress is not without consequences. Due to aggressive treatment protocols that include various combinations of surgery, chemotherapy, and radiation therapy, pediatric sarcoma survivors are at risk of myriad physical, medical, and psychological difficulties as they enter adulthood. These include but are not limited to physical disabilities, chemotherapy-induced cardiac issues, second malignancies, and anxiety. These patients pose unique challenges to their adult primary care physicians. One possible solution to these challenges is multidisciplinary sarcoma survivorship clinics. By paying greater attention to the unique issues of pediatric sarcoma survivors, involved physicians can maximize the physical and emotional health of pediatric sarcoma survivors.
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