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Cytogenetic Abnormalities Found in Patients with Reproductive Problems.
Mirela Mackic-Djurovic1, Sabaheta Hasic2, Emina Kiseljakovic2
1Center for Genetic, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Medical Archives (Sarajevo, Bosnia and Herzegovina)
|February 9, 2018
Summary
Chromosomal aberrations are a significant cause of male infertility. This study found a 6% incidence of chromosomal abnormalities in infertile men, highlighting the importance of cytogenetic analysis for reproductive health.
Area of Science:
- Human Genetics
- Reproductive Medicine
- Cytogenetics
Background:
- Chromosomal aberrations are a key factor contributing to male infertility.
- Understanding these aberrations is crucial for diagnosing and managing male reproductive health issues.
Purpose of the Study:
- To determine the frequency and types of chromosomal aberrations in infertile/sterile men.
- To analyze cytogenetic data from the Center for Cytogenetics, University of Sarajevo (2013-2016).
Main Methods:
- Karyotyping performed on peripheral blood lymphocytes from 353 infertile men (ages 22-55).
- Giemsa trypsin banding (GTG) technique utilized for detailed chromosome analysis.
Main Results:
- A 6% incidence (20/353) of chromosomal aberrations was identified in infertile men.
- Structural abnormalities (85%) were more common than numerical aberrations (15%).
- Robertsonian and reciprocal translocations were the most frequent types, each at 35%.
Conclusions:
- Cytogenetic analysis is vital for diagnosing male infertility.
- Findings support the utility of cytogenetic screening in male infertility, particularly for assisted reproduction techniques.
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