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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
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Aging and the Krüppel-like factors.

Paishiun N Hsieh1,2, David R Sweet1,2, Liyan Fan1,2

  • 1Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

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|February 9, 2018
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Summary

Mammalian Krüppel-like factors (KLFs), transcription factors, are increasingly recognized for their role in aging. This review explores their functions in aging processes and age-related diseases.

Keywords:
KLFKrüppel-like transcription factorsagingaging-associated diseasechronic diseasehealthspanlifespan

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Area of Science:

  • Molecular Biology
  • Genetics
  • Gerontology

Background:

  • Mammalian Krüppel-like factors (KLFs) are a diverse family of transcription factors.
  • These factors exhibit varied expression patterns and cellular functions.
  • Their established roles in mammalian physiology are expanding to include aging.

Purpose of the Study:

  • To review current knowledge on Krüppel-like factors (KLFs).
  • To focus on the specific roles of KLFs in aging processes.
  • To examine the involvement of KLFs in age-associated diseases.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of studies on KLF expression and function.
  • Synthesis of data on KLFs in aging and disease models.

Main Results:

  • KLFs play significant roles in fundamental aging processes.
  • Specific KLFs are implicated in the development of age-related diseases.
  • Understanding KLF functions offers insights into aging mechanisms.

Conclusions:

  • Krüppel-like factors are critical regulators of aging.
  • Targeting KLFs may offer therapeutic strategies for age-associated conditions.
  • Further research into KLFs is essential for advancing gerontology.