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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Potential Energy

Potential Energy

The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...

Potential Energy

Potential Energy

A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...

Standard Electrode Potentials

Standard Electrode Potentials

On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...

Cell Potential and Free Energy

Cell Potential and Free Energy

Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...

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lncRNA in HNSCC: challenges and potential.

Kacper Guglas^1,2, Marta Bogaczyńska^1,3, Tomasz Kolenda^1,2,4

¹Laboratory of Cancer Genetic, Greater Poland Cancer Centre, Poznan, Poland.

Contemporary Oncology (Poznan, Poland)

|February 9, 2018

Summary

Long non-coding RNAs (lncRNAs) are increasingly recognized as potential biomarkers for head and neck squamous cell carcinoma (HNSCC). This review explores their role in HNSCC diagnosis, prognosis, and targeted treatment strategies.

Keywords:

HNSCC biomarkers head and neck lncRNA

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Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Head and neck squamous cell carcinoma (HNSCC) is a significant global health concern with currently unsatisfactory treatment outcomes.
Dysregulation of long non-coding RNAs (lncRNAs) is observed in HNSCC, correlating with tumor progression, metastasis, and patient prognosis.

Purpose of the Study:

To review the potential of lncRNAs as novel biomarkers for HNSCC.
To discuss the characteristics and functions of lncRNAs relevant to HNSCC diagnosis, prognosis, and therapy.

Main Methods:

Literature review focusing on studies investigating lncRNAs in HNSCC.
Analysis of lncRNA features including origin, extraction, stability, detection, and normalization.
Exploration of lncRNA functions in HNSCC pathogenesis and as potential therapeutic targets.

Main Results:

lncRNAs are non-protein-coding RNA molecules with regulatory roles in gene expression and chromatin structure.
Specific lncRNAs are differentially expressed in HNSCC and linked to clinical parameters.
lncRNAs show promise for improving HNSCC diagnosis, predicting patient outcomes, and guiding targeted treatments.

Conclusions:

lncRNAs represent a promising class of biomarkers for head and neck squamous cell carcinoma.
Further research into lncRNA features and functions can advance HNSCC management and therapeutic strategies.