Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

X-Inactivation01:58

X-Inactivation

42.7K
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
42.7K
Blood Flow01:29

Blood Flow

76.4K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
76.4K
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

8.2K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
8.2K
Applications of Integration to Find Blood Flow01:27

Applications of Integration to Find Blood Flow

64
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
64
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

11.7K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
11.7K
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

987
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
987

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-invasive biomechanical characterization of embryos using microfluidic cantilevers.

European biophysics journal : EBJ·2026
Same author

Preliminary Insights into the Acute Molecular Responses in C2C12 Myotubes to Hyperthermia and Insulin Treatment.

bioRxiv : the preprint server for biology·2025
Same author

Design, fabrication, and calibration of a micromachined thermocouple for biological applications in temperature monitoring.

Biosensors & bioelectronics·2024
Same author

Author Correction: Vitamin E inhibits the UVAI induction of "light" and "dark" cyclobutane pyrimidine dimers, and oxidatively generated DNA damage, in keratinocytes.

Scientific reports·2024
Same author

Characterizing induced pluripotent stem cells and derived cardiomyocytes: insights from nano scale mass measurements and mechanical properties.

Nanoscale advances·2024
Same author

Single-Cell Analysis of Contractile Forces in iPSC-Derived Cardiomyocytes: Paving the Way for Precision Medicine in Cardiovascular Disease.

International journal of molecular sciences·2023

Related Experiment Video

Updated: Feb 14, 2026

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
08:25

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Published on: April 6, 2022

2.3K

Light-based methods for whole blood bacterial inactivation enabled by a recirculating flow system.

Gwangseong Kim1,2, Mahsa Karbaschi3, Marcus Cooke3

  • 1Kytaro, Inc., Miami, FL.

Photochemistry and Photobiology
|February 9, 2018
PubMed
Summary

This study demonstrates effective pathogen inactivation in whole blood using light-based methods like photodynamic therapy (PDT) and UV/violet light. These techniques show promise for treating blood infections with minimal damage to blood cells.

More Related Videos

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
05:13

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

Published on: January 24, 2025

839
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.6K

Related Experiment Videos

Last Updated: Feb 14, 2026

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
08:25

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Published on: April 6, 2022

2.3K
LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
05:13

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

Published on: January 24, 2025

839
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.6K

Area of Science:

  • Biomedical Engineering
  • Photomedicine
  • Infectious Disease Research

Background:

  • Whole blood's opacity limits light penetration for pathogen inactivation.
  • Developing effective light-based antimicrobial strategies for blood is crucial.

Purpose of the Study:

  • To evaluate light-based techniques for inactivating pathogens in whole blood.
  • To assess the safety and efficacy of these methods on blood components and cellular DNA.

Main Methods:

  • Utilized a thin transparent tube for 360-degree light illumination of whole blood.
  • Tested photodynamic therapy (PDT), ultraviolet (UV), and violet light for pathogen inactivation.
  • Assessed effects on Staphylococcus aureus, MRSA, peripheral blood mononuclear cells (PBMCs), and genotoxicity.

Main Results:

  • Achieved significant reductions in S. aureus (55-71%) and MRSA (88-97%) with light-based methods.
  • Combined immunocapture with light further enhanced pathogen reduction (up to 99.9%).
  • Minimal changes in blood cell counts; UV/violet light showed low genotoxicity in PBMCs, while PDT induced some DNA damage.

Conclusions:

  • Light-based pathogen inactivation in whole blood is feasible using novel illumination techniques.
  • PDT, UV, and violet light show potential for bloodborne pathogen treatment with manageable safety profiles.
  • Further research is warranted to optimize these methods for clinical application.