Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Rhythmic metrazol activity and cortical spreading depression.

M Pohl, P Mares

Physiologia Bohemoslovaca

|January 1, 1986

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparing conventional, peripheral, and transition zone prostate-specific antigen densities for the detection of clinically significant prostate cancer.

Clinical radiology·2025

Same author

Early Mortality After Curative-intent Radiotherapy in Patients With Locally Advanced Non-small Cell Lung Cancer-A Population-based Cohort Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024

Same author

Temporal Structures in Electron Spectra and Charge Sign Effects in Galactic Cosmic Rays.

Physical review letters·2023

Same author

Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2023

Same author

Properties of Daily Helium Fluxes.

Physical review letters·2022

Same author

Thorough design and pre-trial quality assurance (QA) decrease dosimetric impact of delineation and dose planning variability in the STRICTLUNG and STARLUNG trials for stereotactic body radiotherapy (SBRT) of central and ultra-central lung tumours.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2022

Rhythmic metrazol activity (RMA) originates in the cortex, not the thalamus, in rats. Cortical spreading depression impairs but does not eliminate RMA generalization.

Area of Science:

Neuroscience
Neurophysiology
Epileptology

Background:

Rhythmic metrazol activity (RMA) is a model for studying seizure generation.
The roles of the cortex, thalamus, and hippocampus in RMA generation are not fully understood.

Purpose of the Study:

To investigate the origin and propagation of RMA in the rat brain.
To determine the effect of cortical spreading depression on RMA.

Main Methods:

Acute experiments were conducted on nine male albino laboratory rats.
Metrazol was administered intraperitoneally (50 mg/kg).
Cortical spreading depression was induced to observe its effects on RMA.

Main Results:

The thalamus is incapable of isolated RMA production.

Related Experiment Videos

The cortex can produce RMA independently of the thalamus and hippocampus.

RMA likely originates in the cortex.

Cortical spreading depression impairs, but does not eliminate, RMA generalization.

The hippocampus produces a distinct type of rhythmic activity.

Conclusions:

The cortex is the primary generator of RMA.
Cortical spreading depression significantly impacts RMA propagation and generalization.
The hippocampus exhibits independent rhythmic activity, distinct from RMA.