Extended Release Liposomal Bupivacaine Injection (Exparel) for Early Postoperative Pain Control Following

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Kristopher M Day1, Narayanan M Nair, Devan Griner

  • 1Department of Plastic Surgery, University of Tennessee College of Medicine, Chattanooga, TN.

The Journal of Craniofacial Surgery
|February 9, 2018
PubMed

Insights

Liposomal bupivacaine (LB) offers improved pain control in pediatric pharyngoplasty patients. This long-acting anesthetic led to earlier oral intake, reduced opioid use, and shorter hospital stays.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery
  • Pain Management

Background:

  • Liposomal bupivacaine (LB) is a long-acting local anesthetic.
  • Previous studies suggest LB can decrease postoperative pain.
  • This study evaluates the safety and efficacy of LB in pediatric pharyngoplasty.

Purpose of the Study:

  • To assess the effectiveness of liposomal bupivacaine in pediatric patients undergoing pharyngoplasty.
  • To compare pain scores, oral intake, opioid requirements, and hospitalization duration between LB and traditional anesthetics.

Main Methods:

  • Retrospective case-control study of pediatric pharyngoplasty patients (March 2010-June 2016).
  • Treatment group received LB plus bupivacaine and epinephrine.
  • Control group received lidocaine and epinephrine.

Main Results:

  • LB group showed significantly lower initial pain scores.
  • The LB group tolerated oral intake earlier and in greater volumes.
  • Patients receiving LB required fewer opioids and had shorter hospital stays.

Conclusions:

  • Liposomal bupivacaine is safe and effective for pediatric pharyngoplasty.
  • LB use is associated with reduced opioid consumption.
  • LB facilitates earlier oral intake and shorter hospitalizations in pediatric surgical patients.
Abstract

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