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Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence
Li Zhu1, Yuan Zong2,3, Jian Yu2,3
1Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.
Journal of Glaucoma
|February 9, 2018
Summary
Primary angle closure glaucoma (PACG) significantly reduces retinal vessel density, especially in the peripapillary area. This finding highlights the impact of PACG on ocular blood flow and its correlation with intraocular pressure.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Primary angle closure glaucoma (PACG) is a leading cause of irreversible blindness worldwide.
- Understanding the microvascular changes in PACG is crucial for early diagnosis and treatment.
- Retinal vasculature alterations may serve as an indicator of disease severity and progression.
Purpose of the Study:
- To investigate and quantify changes in retinal vessel density within different fundus regions of eyes affected by primary angle closure glaucoma (PACG).
- To compare retinal vascularization in PACG patients with healthy individuals.
- To explore the relationship between retinal vessel density, intraocular pressure, and disease control in PACG.
Main Methods:
- Employed optical coherence tomography (OCT) and a split-spectrum amplitude decorrelation angiography (SSADA) algorithm.
- Quantified retinal vessel densities in the parafoveal and peripapillary regions.
- Included 39 eyes from 24 PACG patients and 39 eyes from 20 healthy controls, matched for age and sex.
Main Results:
- Significantly lower retinal vessel densities were observed in both parafoveal and peripapillary areas of PACG eyes compared to healthy eyes.
- The reduction in vessel density was more pronounced in the peripapillary area (11.75%) than in the parafoveal area (7.55%).
- Peripapillary vessel density correlated with intraocular pressure in PACG eyes, unlike parafoveal density. Eyes with uncontrolled intraocular pressure showed significantly lower peripapillary vessel density and retinal nerve fiber layer thickness.
Conclusions:
- Retinal vessel density is significantly diminished in eyes with primary angle closure glaucoma.
- The extent of this vascular reduction varies by fundus location, being greater in the peripapillary region.
- Peripapillary vascular changes in PACG are linked to intraocular pressure control, suggesting a potential role in disease monitoring.
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