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Related Concept Videos

Mismatch Repair

Mismatch Repair

Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

Overview of DNA Repair

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Nucleotide Excision Repair

Nucleotide Excision Repair

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

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Related Experiment Video

Updated: Feb 14, 2026

A Mouse Fetal Skin Model of Scarless Wound Repair

A Mouse Fetal Skin Model of Scarless Wound Repair

Published on: January 16, 2015

Embryonic skin development and repair.

Michael S Hu^1,2, Mimi R Borrelli¹, Wan Xing Hong¹

¹a Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.

|February 9, 2018

Summary

This summary is machine-generated.

Fetal skin heals without scarring by regenerating tissue. Adult skin heals with scars, but understanding fetal healing could promote scarless repair in adults.

Keywords:

cutaneous embryogenesis fetal wound healing regeneration scarless scarring wound healing

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Last Updated: Feb 14, 2026

A Mouse Fetal Skin Model of Scarless Wound Repair

A Mouse Fetal Skin Model of Scarless Wound Repair

Published on: January 16, 2015

Ex vivo Culture of Mouse Embryonic Skin and Live-imaging of Melanoblast Migration

Ex vivo Culture of Mouse Embryonic Skin and Live-imaging of Melanoblast Migration

Published on: May 19, 2014

A System for ex vivo Culturing of Embryonic Pancreas

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

Area of Science:

Regenerative medicine
Developmental biology
Wound healing research

Background:

Fetal cutaneous wounds exhibit scarless regeneration, a stark contrast to adult wound healing.
Adult wound healing is characterized by a fibroproliferative response, leading to scar formation.
The mechanisms underlying fetal scarless healing hold significant clinical implications for adult regenerative therapies.

Purpose of the Study:

To review embryonic skin development and compare fetal and adult wound healing phenotypes.
To explore the structural and functional differences between fetal and adult cutaneous wound healing.
To discuss current advancements in applying fetal healing principles to adult wound care.

Main Methods:

Review of scientific literature on embryonic skin development.
Comparative analysis of fetal and adult wound healing processes.
Synthesis of current research on scarless wound healing applications.

Main Results:

Fetal skin possesses unique regenerative capabilities absent in adult skin.
Significant structural and functional disparities exist in wound healing between fetal and adult skin.
Current research is exploring strategies to recapitulate fetal healing in adult wounds.

Conclusions:

Understanding fetal scarless wound healing is crucial for developing novel therapeutic strategies.
Harnessing fetal regenerative mechanisms offers potential for scar reduction and improved skin repair in adults.
Further research into developmental biology can unlock advanced approaches to adult wound management.