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Updated: Feb 14, 2026
05:31
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
Published on: September 20, 2020
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Adjuvant Transarterial Chemoembolization for HBV-Related Hepatocellular Carcinoma After Resection: A Randomized
Zheng Wang1, Zhenggang Ren1, Yi Chen1
1Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China.
Summary
Adjuvant transarterial chemoembolization (TACE) significantly improves recurrence-free survival and overall survival in patients with HBV-related hepatocellular carcinoma (HCC) at intermediate or high risk of recurrence after surgery. The treatment was well-tolerated with no severe toxicity.
Area of Science:
- Hepatocellular Carcinoma (HCC) Research
- Transarterial Chemoembolization (TACE) Applications
- Hepatitis B Virus (HBV) Infection Oncology
Background:
- Hepatocellular carcinoma (HCC) recurrence after curative resection is associated with poor patient survival.
- Identifying effective adjuvant therapies for HBV-related HCC patients with intermediate or high recurrence risk is crucial.
Purpose of the Study:
- To evaluate the safety and efficacy of adjuvant transarterial chemoembolization (TACE) in HBV-related HCC patients.
- To assess the impact of adjuvant TACE on recurrence-free survival (RFS) and overall survival (OS) in high-risk HCC patients.
Main Methods:
- A randomized phase 3 trial involving 280 eligible patients with HBV-related HCC.
- Patients were assigned to either adjuvant TACE (n=140) or no adjuvant treatment (control, n=140).
- Recurrence-free survival (RFS) was the primary endpoint; overall survival (OS) and safety were secondary endpoints.
Main Results:
- Adjuvant TACE significantly improved RFS compared to the control group (56.0% vs. 42.1%, P=0.01).
- Patients receiving adjuvant TACE showed a higher 3-year OS rate (85.2% vs. 77.4%, P=0.04).
- No grade 3 or 4 toxicity was observed in the adjuvant TACE group.
Conclusions:
- Adjuvant TACE significantly reduces tumor recurrence in HBV-related HCC patients at intermediate or high risk post-surgery.
- The study demonstrates improved RFS and OS with adjuvant TACE, indicating its clinical benefit.
- Adjuvant TACE is a safe and well-tolerated treatment option for this patient population.
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