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Updated: Feb 14, 2026
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Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
Published on: July 21, 2016
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Placental Findings in Singleton Stillbirths: A Case-control Study
Anitha Ananthan1, Ruchi Nanavati1, Pragati Sathe2
1Department of Neonatology, Seth G. S. Medical College and KEM Hospital, Mumbai, India.
Journal of Tropical Pediatrics
|February 9, 2018
Summary
Placental lesions like abruption and gestational diabetes were more common in stillbirths. Abnormal placental findings, including delayed maturation and villitis, were significantly increased in stillbirth cases.
Area of Science:
- Perinatal pathology
- Obstetrics
- Fetal medicine
Background:
- Stillbirth remains a significant concern in perinatal medicine, with many cases lacking a clear etiological explanation.
- Placental examination is crucial for understanding fetal demise and identifying potential contributing factors.
Purpose of the Study:
- To compare placental lesions between stillbirth cases and live birth controls.
- To investigate the role of placental abnormalities in the etiology of stillbirth.
Main Methods:
- A prospective observational study comparing 85 stillbirths and 85 live births.
- Histopathological examination of placental tissues from both groups.
- Statistical analysis to determine significant differences in placental findings.
Main Results:
- Increased incidence of placental abruption and gestational diabetes in mothers with stillbirths.
- Significantly higher rates of abnormal placental histopathology in stillbirths.
- Elevated occurrences of delayed villous maturation, acute and chronic diffuse villitis, chorionic plate acute vasculitis, fetal vascular thrombi, and avascular villi in stillbirth placentas.
Conclusions:
- Abnormal placental patterns are significantly associated with stillbirth.
- These findings can contribute to understanding the etiopathogenesis of stillbirths, particularly those with unknown causes.
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